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Vitamin B6
Vitamin B6, also called pyridoxine, is one of eight water-soluble B vitamins. The B vitamins help the body to convert carbohydrates into glucose (sugar), which is "burned" to produce energy. These vitamins, often referred to as the B complex, are also essential in the metabolism of fats and protein. B complex vitamins also play an important role in maintaining muscle tone in the gastrointestinal tract and promoting the health of the nervous system, skin, hair, eyes, mouth, and liver. Vitamins B12, B6, and B9 (folic acid) work closely together to control blood levels of the amino acid homocysteine. Elevated levels of this substance appear to be linked to heart disease. Plus, vitamin B6 is essential for normal brain development and function, participating in the process of making important brain chemicals called neurotransmitters. Pyridoxine is an especially important vitamin for maintaining healthy nerve and muscle cells and it aids in the production of DNA and RNA, the body's genetic material. It is necessary for proper absorption of vitamin B12 and for the production of red blood cells and cells of the immune system. Pyridoxine has also been called the "woman's vitamin" because it may help relieve symptoms of premenstrual syndrome (PMS). In addition to other B complex vitamins, pyridoxine is considered an "anti-stress" vitamin because it is believed to enhance the activity of the immune system and improve the body's ability to withstand stressful conditions. Symptoms of pyridoxine deficiency include muscle weakness, nervousness, irritability, depression, difficulty concentrating, and short-term memory loss.
Low dietary intake of vitamin B6 is associated with higher risk of having heart disease. This may be related to the fact that vitamin B6, together with vitamin B9 (folic acid) and vitamin B12, help to keep homocysteine levels under control. Homocysteine is an amino acid. Elevated levels of this amino acid are associated with increased risk of heart disease and increased risk of stroke. The American Heart Association recommends, for most people, that enough of these important B vitamins be obtained from the diet, rather than taking extra supplements. Under certain circumstances, however, supplements may be necessary. Such circumstances include elevated homocysteine levels with known heart disease or strong family history of heart disease at a young age.
A recent review of scientific studies concluded that vitamin B6 may help reduce the severity of nausea during early pregnancy.
Keeping bones healthy throughout life depends on getting sufficient amounts of specific vitamins and minerals, including phosphorous, magnesium, boron, manganese, copper, zinc, folate, and vitamins C, K, B6, and B12.
Levels of important nutrients are often quite low in those with anorexia or bulimia. At least 20% of people with anorexia admitted to a hospital for treatment are deficient in vitamins B2 and B6 (pyridoxine). Some research information suggests that as many as 33% of those with an eating disorder could be deficient in vitamins B2 and B6. Dietary changes alone, without additional supplements, can often bring vitamin B levels back to normal. However, extra B2 and B6 may be required (which will be determined by your doctor or nutritionist). Plus, B-complex vitamins may help alleviate stress and reduce symptoms of depression, frequently associated with eating disorders. Recommended for joints Glucosamine

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Precautions
It is especially important for people who have sustained serious burns to obtain adequate amounts of nutrients in their daily diet. When skin is burned, a substantial percentage of micronutrients may be lost. This increases the risk for infection, slows the healing process, prolongs the hospital stay, and even increases the risk of death. Although it is unclear which micronutrients are most beneficial for people with burns, many studies suggest that a multivitamin including the B complex vitamins may aid in the recovery process. Vitamin B6, along with other members of the B complex, may be of particular importance, given their value in building protein. Protein is necessary to recover from any kind of an injury. In addition, as stated earlier, the amount of B complex needed may increase during times of stress.
Studies suggest that vitamin B9 (folate) may be associated with depression more than any other nutrient. Between 15% and 38% of people with depression have low folate levels in their bodies and those with very low levels tend to be the most depressed. Many healthcare providers start by recommending a multivitamin (MVI) that contains folate, and then monitoring the homocysteine levels in the blood to ensure the adequacy of therapy. Elevated homocysteine levels indicate a deficiency of folate even if the levels of folate in the blood are normal. If the MVI alone is not enough to lower homocysteine and improve folate function, the provider may suggest additional folate along with vitamins B6 and B12 to try to bring the homocysteine levels down, thereby eliminating the functional folate deficiency and, hopefully, helping to improve feelings of depression.
A comprehensive review of studies concluded that vitamin B6 may be more effective than placebo in improving symptoms of PMS, particularly depression. Most studies were poorly designed, however. Still, even though the science is not definitive, many healthcare providers and their female patients report improvement in PMS from using vitamin B6. Therefore, how well you respond to vitamin B6 may be very individual. Until more research is completed, talk with your doctor about whether using B6 is appropriate and safe for you. Then, if taking the vitamin, follow your symptoms closely. It can take up to 3 months until any change is noticeable.

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