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Allopurinol
HEALTH INFORMATION: Allopurinol Uses
Allopurinol (Zyloprim) is used in the treatment of many symptoms of gout, including acute attacks, tophi (collection of uric acid crystals in the tissues, especially around joints), joint destruction, and uric acid stones. Gout is a form of arthritis characterized by increased blood levels of uric acid. Allopurinol (Zyloprim) works by reducing uric acid production in the body, thus preventing crystals from forming. Zyloprim is also used to manage the increased uric acid levels in the blood of people with certain cancers, such as leukemia. It is also prescribed to manage some types of kidney stones. This medicine works by causing less uric acid to be produced by the body. Allopurinol will not relieve a gout attack that has already started. Also, it does not cure gout, but it will help prevent gout attacks. However, it works only after you have been taking it regularly for a few months. Allopurinol will help prevent gout attacks only as long as you continue to take it. Allopurinol is also used to prevent or treat other medical problems that may occur if too much uric acid is present in the body. These include certain kinds of kidney stones or other kidney problems.
Allopurinol How To Take
Take Zyloprim exactly as prescribed. Your doctor will probably start you on a low dosage, increasing it gradually each week until you reach the dosage that is best for you. A typical starting dose is one 100-milligram tablet per day. You may want to take Zyloprim immediately after a meal to minimize the risk of stomach irritation. You should avoid taking large doses of vitamin C because of the increased possibility of kidney stone formation. While taking Zyloprim you should drink plenty of liquids--10 to 12 glasses (8 ounces each) per day--unless otherwise prescribed by your doctor.
Allopurinol Side Effects
Side effects of allopurinol cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyloprim. Because a skin reaction, the most common side effect of Zyloprim, may occasionally become severe or even fatal, you should stop taking Zyloprim if you notice even the beginnings of a rash. Such a rash may be itchy or scaly or may make your skin peel off in sheets; it may be accompanied by chills and fever, aching joints, or jaundice.
More common side effects may include:
Acute attack of gout, diarrhea, nausea, rash
Less common or rare side effects may include:
Abdominal pain, bruising, chills, fever, hair loss, headache, hepatitis, hives, indigestion, itching, joint pain, kidney failure, loosening of nails, muscle disease, nosebleed, rare skin condition characterized by severe blisters and bleeding on the lips, eyes, or nose, reddish-brown or purplish spots on skin, skin inflammation or peeling, sleepiness, stomach inflammation, taste loss or change, tingling or pins and needles, unusual bleeding, vomiting, yellowing of skin and eyes
Allopurinol Medical Precautions
If you notice a rash or other signs of an allergic reaction, stop taking Zyloprim immediately and consult your doctor. In some people,
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a Zyloprim-induced rash may lead to a serious skin disease, generalized inflammation of a blood or lymph vessel, irreversible liver damage, or even death. You may experience acute attacks of gout more often in the early stages of Zyloprim therapy, even when normal uric acid levels have been attained. These attacks will become shorter and less severe after several months of therapy. A kidney problem may turn a normal dose of Zyloprim into an overdose. If you have a kidney disease, or a condition such as diabetes or high blood pressure that may affect your kidneys, your doctor should prescribe Zyloprim cautiously and order periodic blood and urine tests to assess your kidney function. Because Zyloprim may make you drowsy, do not drive or perform hazardous tasks until you know how the medication affects you. It may be 2 to 6 weeks before you see any results from this medication.
Allopurinol Drug Interactions
If Zyloprim is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zyloprim with the following:
Amoxicillin (Amoxil, Trimox, Wymox)
Ampicillin (Omnipen, Principen)
Cyclosporine (Sandimmune, Neoral)
Drugs for diabetes, such as Diabinese and Orinase
Mercaptopurine (Purinethol)
Azathioprine (Imuran)
Blood thinners such as Coumadin
Probenecid (Benemid, ColBENEMID)
Sulfinpyrazone (Anturane)
Thiazide diuretics such as HydroDIURIL, Diuril, and others
Vitamin C
Theophylline (Theo-Dur, Slo-Phyllin, and others)
Allopurinol Missed Dosages
If you miss a dose take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.
Allopurinol Storage
Store at room temperature in a cool, dry place, away from light.

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